EVALUATION OF MICELLES INCORPORATED INTO THERMOSENSITIVE HYDROGELS FOR INTRATUMORAL DELIVERY AND CONTROLLED RELEASE OF DOCETAXEL: A DUAL APPROACH FOR IN SITU TREATMENT OF TUMORS

The in situ gelling hybrid hydrogel system has been reported to effectively concentrate chemotherapeutic drugs at the tumor site and sustain their CHOCOLATE MACAROONS release for a long period.DTX-micelles (docetaxel-loaded mixed micelles) are able to increase the solubility of DTX in water, and then a high drug loading rate of hydrogels can be ach

Cai-Tao Chen,1 Chun-Xiao Shan,2 Jun Ran,3 Lei-Miao Yin,1 Hai-Yan Li,4 Yu Wang,1 Yu-Dong Xu,1 Jing-Lei Guo,5 Yang-Lin Shi,1 Yan-Jiao Chen,1 Yong-Qing Yang1 1Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P

Elmir Omerovic, Gerhard Brohall, Markus Müller, Truls Råmunddal, Göran Matejka, Finn Waagstein, Björn FagerbergThe Wallenburg Laboratory at Sahlgrenska Academy, Department of Cardiology, Sahlgrenska University Hospital, Gothenburg University, 413 45, Gothenburg, Sweden; Department of Cardiology and Department of

Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription factors (CRTFs).P3F recruits co-regulatory factors to super enhancers such as BRD4, which recogni

Rice analogs are rice-like products processed from various non-rice carbohydrate sources, such as corn flour.A high-protein rice analog can be produced with the addition of soybean into the formula of corn-based rice analog.This research aimed to evaluate a high-protein rice analogs made with the addition of soybeans (Grobogan or Detam-1 variety) i